System Medicine

Doctoral programme (PhD)
A.Y. 2021/2022
Study area
Medicine and Healthcare
The Medicine field is going through a cultural revolution, pressed by the new knowledge emerging from the fundamental biology (molecular biology, and, more recently, genomics). This knowledge has brought to the development of the Personalized Medicine, based on the identification of the mechanisms in the disease, specific to the given disease and to the patient, and the consequent molecular treatments. Although the Personalized Medicine changed the story of some diseases, for some others there exists a rising discrepancy between the scientific discoveries and their turning into a benefit for the patient. This discrepancy is considered a problem by both the scientific community and the society. The aim of the PhD course is the training of a new generation of basic researchers, able to follow the changes occurring in the biomedicine.
The fundamental elements of the training program are:
· the introduction of basic subjects (mathematics, physics, informatics, statistics);
· the teaching of new models of Translational Research, where the basic researchers work along with the clinicians on the same biomedical problems;
· the foundation of a humanistic culture of the new scientific discoveries (foundational, ethical and sociological basis) and the operative tools (cognitive sciences) which allow the new scientists to interact with the society (patients, policy-makers).
The fundamental elements of the training program are:
· the introduction of basic subjects (mathematics, physics, informatics, statistics);
· the teaching of new models of Translational Research, where the basic researchers work along with the clinicians on the same biomedical problems;
· the foundation of a humanistic culture of the new scientific discoveries (foundational, ethical and sociological basis) and the operative tools (cognitive sciences) which allow the new scientists to interact with the society (patients, policy-makers).
Tutte le classi di laurea magistrale - All classes of master's degree
Dipartimento di Oncologia ed Emato-Oncologia - Via Festa del Perdono, 7 - Milano
- Main offices
Dipartimento di Oncologia ed Emato-Oncologia - Via Festa del Perdono, 7 - Milano - Degree course coordinator: Saverio Minucci
[email protected] - Degree course website
https://www.semm.it/education
Title | Professor(s) |
---|---|
Dissecting the epigenetic role of Transposable Elements in tumor infiltrating lymphocytes
Curriculum: Molecular Oncology |
|
Tissue infiltrating T lymphocytes in health and disease: new approaches to dissect identity, geography and function of tissutal T cells and to discover new targets for precision immunotherapy
Curriculum: Molecular Oncology |
|
Evaluation of the risk of secondary leukemias in cancer survivors
Curriculum: Molecular Oncology |
|
Functional Genomics
Curriculum: Molecular Oncology |
|
Combinatorial targeting of MYC- and BCL2-driven lymphoma
Curriculum: Molecular Oncology |
B. Amati
|
Oncogenes, Transcription and Cancer
Curriculum: Molecular Oncology |
B. Amati
|
Proteomics elucidation of tumor microenvironment
Curriculum: Molecular Oncology |
A. Bachi
|
Functional Proteomics
Curriculum: Molecular Oncology |
A. Bachi
|
Epi-proteomics approach to investigate the role of protein-post translational modifications in tumorigenesis, chemoresistance and latency
Curriculum: Molecular Oncology |
|
Nuclear Proteomics to Study Gene Expression Regulation in Cancer
Curriculum: Molecular Oncology |
|
An integrative analysis framework between RNA synthesis and decay.
Curriculum: Computational Biology |
L. Calviello
|
RNP dynamics along the mRNA in normal and mis-regulated translation.
Curriculum: Computational Biology |
L. Calviello
|
Characterizing the role of heterogeneous RNPs and their dynamics along the mRNA
Curriculum: Computational Biology |
L. Calviello
|
Proteogenomics applications between RNA and protein
Curriculum: Computational Biology |
L. Calviello
|
Regulation of chromatin activity by interactome with non-coding RNA classes
Curriculum: Computational Biology |
P. Carninci
|
Functional Genomics
Curriculum: Computational Biology |
P. Carninci
|
Molecular Mechanisms of mRNA Modifying Machines
Curriculum: Molecular Oncology |
A. Casanal
|
RNA modifications and their role
Curriculum: Molecular Oncology |
A. Casanal
|
Thyroid Biology
Curriculum: Molecular Oncology |
F. Coscia
|
Structural and functional characterisation of thyroid proteins involved in cancer, autoimmunity and hormone synthesis defects
Curriculum: Molecular Oncology |
F. Coscia
|
Understanding how vertebrate stem cells maintain genome stability
Curriculum: Molecular Oncology |
|
The role of DNA repair and DNA damage response proteins in vertebrate stem cells, embryonic development and cancer
Curriculum: Molecular Oncology |
|
Exploring the links between cancer and stem cells
Curriculum: Molecular Oncology |
|
DNA Methabolism
Curriculum: Molecular Oncology |
|
Aging as a telomere biology disorder
Curriculum: Molecular Oncology |
F. D'Adda di Fagagna
|
DNA damage Response and Cellular Senescence
Curriculum: Molecular Oncology |
F. D'Adda di Fagagna
|
Deciphering patterns of genetic convergence disrupting human brain development via integrative single-cell multi-omics
Curriculum: Computational Biology |
J. Davila-Velderrain
|
Cellular complexity of the human brain in development and neurodegeneration
Curriculum: Computational Biology |
J. Davila-Velderrain
|
Endocytosis, signaling and cancer
Curriculum: Molecular Oncology |
|
Endocytosis, cancer stem cells and metastasis
Curriculum: Molecular Oncology |
|
Molecular and structural investigation of the p53 regulatory pathway mediated by the numb isoforms
Curriculum: Molecular Oncology |
|
Modelling bacterial and viral infections in organoids using cryo-electron tomography
Curriculum: Molecular Oncology |
P. Erdmann
|
The Development of a Novel Human Pluripotent Stem Cell-Based Organoid System to Study Host-Virus interactions in the Central Nervous System
Curriculum: Molecular Oncology |
O. Harschnitz
|
Neuroimmunological disorders
Curriculum: Molecular Oncology |
O. Harschnitz
|
Molecular and cellular mechanisms that underlie susceptibility to viral and autoimmune disease of the human nervous system
Curriculum: Molecular Oncology |
O. Harschnitz
|
Dissection of Acute and Chronic Pathology in Autoimmune Encephalitis Using a Highly Defined Human Stem Cell-Derived Co-Culture System
Curriculum: Molecular Oncology |
O. Harschnitz
|
Delineating the landscape of glioblastoma vulnerabilities from the analysis of single-cell omics and Cancer Dependency Map data.
Curriculum: Computational Biology |
F. Iorio
|
Analytical methods for pharmacogenomics
Curriculum: Computational Biology |
F. Iorio
|
Morphology of neural progenitor cells in brain development and neurodevelopmental disorders
Curriculum: Molecular Oncology |
N. Kalebic
|
Molecular mechanisms underlying brain development and evolution
Curriculum: Molecular Oncology |
N. Kalebic
|
Nutrition based methods to identify and enhance targeted cancer therapies
Curriculum: Molecular Oncology |
V. Longo
|
Longevity and Cancer
Curriculum: Molecular Oncology |
V. Longo
|
Nutrition and cancer
Curriculum: Molecular Oncology |
V. Longo
|
Transcription stress and metabolic redesign in rare DNA Repair disorders
Curriculum: Molecular Oncology |
P. G. Mastroberardino
|
Impact of systemic metabolism antitumoral immunity
Curriculum: Molecular Oncology |
L. Mazzarella
|
Translational oncology
Curriculum: Molecular Oncology |
L. Mazzarella
|
Genetic and biophysical determinants of breast cancer metastasis and sensitivity to novel drugs
Curriculum: Molecular Oncology |
L. Mazzarella
|
Methabolism and cancer
Curriculum: Molecular Oncology |
L. Mazzarella
|
The dynamics of the epigenome and adaptation to therapy
Curriculum: Computational Biology |
|
Epigenome and cancer
Curriculum: Computational Biology |
|
The intersection of metabolic adaptations of tumor cells and the regulation of the epigenome
Curriculum: Molecular Oncology |
|
Chromatin Alterations in Tumorigenesis
Curriculum: Molecular Oncology |
|
Characterization of genomic regulatory elements in myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (sAML)
Curriculum: Molecular Oncology |
G. Natoli
|
Transcriptional Control in Inflammation and Cancer
Curriculum: Molecular Oncology |
G. Natoli
|
The role of non-coding genome in cancer disease
Curriculum: Molecular Oncology |
F. Nicassio
|
Noncoding Genome in Development and Disease
Curriculum: Molecular Oncology |
F. Nicassio
|
Mechanistic understanding of Polycomb-mediated regulation of transcriptional identity in oncogenesis
Curriculum: Molecular Oncology |
|
Epigenetic Mechanisms in Cancer
Curriculum: Molecular Oncology |
|
Exploring molecular and cellular mechanisms of cancer progression and metastases
Curriculum: Molecular Oncology |
|
Molecular mechanisms of tumorigenesis
Curriculum: Molecular Oncology |
|
Molecular mechanisms of tumorigenesis from a computational point of view
Curriculum: Computational Biology |
|
Analyses of the genetic and phenotypic evolution at single-cell level of normal and cancer stem cells
Curriculum: Computational Biology |
|
Development of artificial intelligence for multi-parametric MRI of prostate
Curriculum: Computational Biology |
|
Three-dimensional prostate model use and augmented-reality during robot-assisted radical prostatectomy
Curriculum: Computational Biology |
|
Enhancing adherence to behavioral change recommendations and medications among cancer survivors
Curriculum: Medical Humanities |
|
Psycho-social behavior and immune system: DeveIoping an integrated model of care
Curriculum: Medical Humanities |
|
Developing integrated health behavioural models to prevent cancer disease
Curriculum: Medical Humanities |
|
Effects of adjuvant endocrine therapy on cognitive performance in patients with breast cancer: a longitudinal study
Curriculum: Medical Humanities |
|
Healthy aging and the human microbiome
Curriculum: Computational Biology |
N. Segata
|
Cardiometabolic risk in an Italian population
Curriculum: Computational Biology |
N. Soranzo
|
Molecular and genetic control of T cell - B cell interaction and antibody production
Curriculum: Computational Biology |
B. Soskic
|
Variation in the immune system
Curriculum: Computational Biology |
B. Soskic
|
Computational Methods for Single-Cell Cancer Evolution
Curriculum: Computational Biology |
A. Sottoriva
|
Predicting cancer evolution
Curriculum: Computational Biology |
A. Sottoriva
|
Studying the role of intracellular traffic in brain development using cell biology and robotics
Curriculum: Molecular Oncology |
E. Taverna
|
Stem cell identity in brain development
Curriculum: Molecular Oncology |
E. Taverna
|
Organoid-based single cell deconvolution of the health impact of endocrine disruptors
Curriculum: Molecular Oncology |
|
Neurodevelopmental and intergenerational impact of endocrine disruptors
Curriculum: Molecular Oncology |
|
Deep learning approaches to data integration and multi-omic lineage tracing in ovarian cancer
Curriculum: Computational Biology |
|
Single-cell multi-omics deconvolution of neurodevelopmental disorders
Curriculum: Computational Biology |
|
Stem Cell and Organoid Epigenetics
Curriculum: Molecular Oncology |
|
Human brain evolution through the lens of neurodevelopmental disorders
Curriculum: Molecular Oncology |
|
Studying architectural proteins of the human genome by cryo-EM
Curriculum: Molecular Oncology |
A. Vannini
|
Structural studies of protein complexes associated with intellectual disabilities and cancer
Curriculum: Molecular Oncology |
A. Vannini
|
TFEB-mTORC1 signaling in health and disease
Curriculum: Human Genetics |
A. Ballabio
|
Transcriptional regulation of autophagy and lysosomal function
Curriculum: Human Genetics |
A. Ballabio
|
Therapeutic genome editing in retina and liver
Curriculum: Human Genetics |
A. Auricchio
|
Study of Ezrin\TSC\mTORC1 pathway in retina: a new therapeutic target to treat retinal degeneration
Curriculum: Human Genetics |
A. Auricchio
|
The OFD1 transcript:one gene, several disease
Curriculum: Human Genetics |
B. Franco
|
Can down regulation of miR181 be beneficial in Friedreich Ataxia?
Curriculum: Human Genetics |
B. Franco
|
New therapies for inborn errors of liver metabolism
Curriculum: Human Genetics |
N. Brunetti Pierri
|
Development of novel therapies for inborn errors of metabolism
Curriculum: Human Genetics |
N. Brunetti Pierri
|
Gut Microbiome as target for innovative preventive and therapeutic strategies for chronic non-communicable disorders
Curriculum: Human Genetics |
R. Berni Canani
|
Formulated milk administration to children and their hereditary disorders
Curriculum: Human Genetics |
R. Berni Canani
|
Emerging metabolites and enzymes in mammalian central nervous system
Curriculum: Molecular Oncology |
A. Usiello
F. Salvatore
|
Predictive medicine for tumors with their physiopatological molecular aspects
Curriculum: Molecular Oncology |
F. Salvatore
|
Courses list
January 2022
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Biochemistry and Molecular Biology Techniques | 4 | 20 | English |
February 2022
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Cancer Genetics | 2 | 10 | English | |
Scientific Writing | 2 | 10 | English |
March 2022
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Immunology | 3 | 16 | English |
February 2022
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Genomics and Proteomics | 5 | 25 | English | |
Scientific Writing | 2 | 10 | English |
March 2022
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Programming | 8 | 40 | English |
February 2022
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Scientific Writing | 2 | 10 | English |
February 2022
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Scientific Writing | 2 | 10 | English |
May 2022
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Digital Interventions in Applied Psychology | 2 | 10 | English | |
Introduction to Quantitative Data Analysis with Spss | Monzani Dario
|
6 | 30 | English |
July 2022
Courses or activities | Professor(s) | ECTS | Total hours | Language |
---|---|---|---|---|
Compulsory | ||||
Qualitative Data Analysis | 2 | 10 | English |
Following the programme of study
Contacts
Office and services for PhD students and companies