Clinical Research

Dottorati
Doctoral programme (PhD)
A.Y. 2021/2022
Study area
Medicine and Healthcare
Doctoral programme (PhD)
3
Years
Dipartimento di Fisiopatologia medico-chirurgica e dei trapianti, Via F. Sforza, 35 - 20122 Milano
English
PhD Coordinator
Students will learn a correct research approach for studying the causes and the clinical-therapeutic management of diseases.
Specific objectives:
identify clinical issues and uncertainties in pathogenesis, diagnosis, prognosis and in therapeutic approaches in various diseases;
correctly apply different research methodologies (randomized trials, longitudinal, cross-sectional or transversal studies and case control studies);
identify and use biological and genetic markers for studying clinical syndromes, guiding diagnosis and assessing the clinical outcome of different pathologies;
develop critical skills to analyse and comment clinical research results published or presented at national and international conferences;
introduce students to independent clinical research methods and to the issues and critical points relating to ethics in clinical research.
The programme is entirely in English.
Classes of master's degree - Possono presentare domanda di partecipazione al concorso di ammissione al dottorato di ricerca coloro i quali siano in possesso di laurea magistrale LM-41 - Medicina e chirurgia, che, nell'anno accademico 2019/2020, inizieranno il loro ultimo anno di una scuola di specializzazione di area medica dell'Università degli Studi di Milano e laureati magistrali nella LM-41 - Medicina e chirurgia, e in possesso del diploma di specializzazione di area medica.

Possono inoltre presentare domanda di partecipazione i possessori di laurea magistrale in Odontoiatria e protesi dentaria (LM-46).
Dipartimento di Fisiopatologia medico-chirurgica e dei trapianti, Via F. Sforza, 35 - 20122 Milano
Title Professor(s)
1. Evaluation of homologous nerve grafts in the reconstruction of the nerves of the oral cavity. 2. Study of the effectiveness of facial nerve neurorrhaphy in the term-terminal and termino-lateral modalities.
Curriculum: Stomatology
1. Epidemiology of oral diseases especially dental caries 2. Caries prevention agents and their use in populations at high risk of disease 3. Children with Special needs and oral health: preventive and therapeutic strategies 4. Maternal and children's oral health promotion and prevention
Curriculum: Stomatology
Radioprotection in medicine concerning diagnosis treatment and therapy. Risks and benefits evaluation regarding patient characteristics.
Curriculum: Stomatology
1. Comparative mapping of viroma and microbiome of the upper respiratory tract in SARS-CoV-2 patients; 2. Development of an integrated proteomic and metabolomic approach for the treatment of SARS-CoV-2 patients admitted to intensive and subintensive therapies.
Curriculum: Stomatology
Clinical and lab validations of new orthodontic devices
Curriculum: Stomatology
1. Development and clinical application of new collagen xenogenous matrices for the regeneration of intra-oral soft tissues; 2. Development and clinical applications of customized Cad/cam titanium meshes for guided bone regeneration of atrophic edentulous jaws.
Curriculum: Stomatology
Autologous dentin matrix and platelet concentrates for alveolar site preservation and bone defects reconstruction procedures in oral surgery
Curriculum: Stomatology
1. Morphofunctional analyses of organs and tissues of the oral system. 2. Strategies for the prevention of SARS-CoV-2 infection and for the evaluation of its effects on anatomical structures in humans.
Curriculum: Stomatology
1. Modern therapeutic approaches for periodontal and peri-implant diseases. 2. Study of the correlation between periodontal diseases and systemic conditions
Curriculum: Stomatology
1. Interaction of the microbial flora of the oral cavity with modern materials used in Restorative and Prosthetic Dentistry. The line includes the study and synthesis of dental materials with antibacterial and bioactive properties also using nanotechnologies with a bottom-up approach, the study of their surface characteristics, mechanical tests on materials, the development and use of flow bioreactors, the use of optical, SEM, confocal microscopes to the CLSM laser. 2. Development of in vitro models for simulating the microbiological aging of materials for dental use. 3. Development of in vitro microbiological models for the study of demineralization / remineralization of dental hard tissues, also using micro-CT. Development and study of active principles with remineralizing activity. 4. Development of 3D tissue models of reconstituted human epithelium for the evaluation of the efficacy of active ingredients and models of microbial co-infections. 5. Development of flow bioreactor models for the study and prevention of microbial infections of catheters. 6. Development of a protected environment for the evaluation of the spread via aerosol of infections in the clinical setting, in particular for the evaluation of measures to protect the Operators and limit the spread of Coronavirus in the Dental field.
Curriculum: Stomatology
A. Ionescu
Etiopathogenesis, diagnosis, treatment and prognosis of mucosal lesions with particular attention towards potentially malignant ones.
Curriculum: Stomatology
1. Single-phase implants prospective observational study of cohorts. X-ray evaluation of MBL of single-phase implants inserted in full-arch rehabilitations with full-digital approach with immediate load. 2. Matrices for soft tissue growth RCT evaluation of increase of soft tissue with pig collagen matrix placed in the middle and full thickness with scans at 1-3-6-12 months. 3. Increase in perimplantary soft tissues RCT evaluation of soft tissue growth with roll flap vs connective grafting approach.Volumetric and PES 12-month assessment. 1. Peri-implant bone level in implant positioning conditions with partial thickness and full thickness flap. prospective randomized 3-year study 2. Randomized, double-blind, active-controlled, placebo-controlled, parallel group, single dose, multicenter study to evaluate the analgesic effect of CR4056 in postoperative dental pain - ACT 1262/2018 3. Clinical evaluation of the effectiveness of a reabsorbable collagen membrane in guided bone regeneration for implant-prosthetic purposes - ACTS 1124/2017 4. Study of the neuromuscular behavior of the elevating muscles of the jaw (temporal and masseter) and of the cranial postural muscles (sternocleidomastoid and trapezius) as possible indicators of an occluded-postural imbalance in subjects of the ballet dances between 16 and 24 years old
Curriculum: Stomatology
1. Study of the individual resistance determinants and environmental protective factors in Sars-CoV-2 infections in populations with low prevalence of infection. 2. Study of the adaptive immune response to Sars-CoV-2 infections in exposed and non-exposed populations (immunological response through cross-reactivity)
Curriculum: Stomatology
1. New methodological and technological developments in physical and rehabilitation medicine 2. Verification of efficacy of therapies and reliability of outcome measurements in vertebral deformities
Curriculum: Stomatology
1. Regeneration of Periodontal and peri-implant tissues, in particular surgical techniques, scaffolds and growth factors. 2. Development of 3D printed scaffolds for the regeneration of maxillary processes. 3. Identification of "treatable traits" and characterization of "personalized therapy" in asthmatic subjects.
Curriculum: Stomatology
Single edentulism treatment through implant-supported rehabilitation with autologous connective or heterologous matrix graft. Multicentric, randomized controlled study.
Curriculum: Stomatology
1. Impact of chronic facial pain disorders (Burning Mouth Syndrome, Persistent Idiopathic Facial Pain) on the oral, systemic and mental health conditions of patients and their family members.
Curriculum: Stomatology
Evaluation of molecules with anti-biofilm activity for the prevention and treatment of peri-implantitis.
Curriculum: Stomatology
Efficacy of laser biostimulation in pain and oedema reduction after impacted mandibular third molar extraction: multicentric, randomized study.
Curriculum: Stomatology
1. Wearables BioSensor Technologies for Oral Metabolic Agents in saliva - 2. Semiautomatic and Automatic 3D craniofacial analysis through Artificial Intelligence (AI) methods and its application in orthodontics and maxillo-facial surgery.- 3. 3d on chair printed aligners. Validation of their clinical efficacy
Curriculum: Stomatology
1. Intra-operative protection of the saphenous vein used as a graft in cardiac and vascular surgery to allow for greater patency at a distance. 2. Study of the interaction between mechanical and paracrine factors in the progression of saphenous vein bypass disease. 3. Aortic valve insufficiency in relation to left ventricular size: what is the correct surgical timing? 4. Transcatheter aortic implantation (TAVR) in aortic valve disease: a study of access routes
Curriculum: Specialized medical sciences
1. Epidemiology, diagnostic pathways and therapy of protozoan diseases (malaria, leishmaniasis, Chagas disease). 2. Antimicrobial stewardship routes. 3. Characterization of the serological response during COVID-19 infection 4. Therapeutic approaches in patients with severe SARS-COV-2 disease 5. Identification of unfavorable outcome determinants in subjects with COVID-19 infection
Curriculum: Specialized medical sciences
1. Pathophysiology, therapy and complications of hypothalamic-pituitary diseases and hypogonadism. 2. Endocrine diseases and SARS-CoV2 infections: search for prognostic risk factors and disease severity.
Curriculum: Specialized medical sciences
Morphological and functional adaptation of right ventricle ad different stages of pulmonary circulation involvement in heart failure patients with reduced ejection fraction
Curriculum: Specialized medical sciences
1. Treatment of respiratory symptoms related to pathologic gastroesophageal reflux disease and assessment of esophageal patophysiology with 24-pH study and high-tesolution manometry, in patients with systemic slecrosis managed with laparoscopic partial fundoplication. A feasibility study. 2. Management of gastroesophageal reflux disease after sleeve gastrectomy using the esophageal magnetic sphincter augmentation device (LINX): physiopathological evaluation with high-resolution manometry and 24-hour pH-study.
Curriculum: Specialized medical sciences
1. Prehabilitation in upper digestive surgery; 2. Endoscopic screening of gastroesophageal reflux disease and Barrett’s esophagus with brush citology; 3. Hemodynamic effects after repair of large hiatal hernia;
Curriculum: Specialized medical sciences
1. Diseases of the pericardium. 2. Pregnancy in autoimmune diseases. 3. COVID 19: development of multi-arm clinical trials with immunotherapy. 4. COVID 19: hospitalization data analysis and epidemiological and clinical research. 5. Vasculitis: pathogenesis, diagnosis, therapy, folow-up. 6. Fragile non-oncological patient in advanced disease phase: prognostic score.
Curriculum: Specialized medical sciences
1. Innovative approaches to early diagnosis of Autism Spectrum Disorders 2. Multidisciplinary characterization of epilepsy and/or neurodevelopmental disorders 3. Central Nervous System involvement in Sars-Cov-2 Infection
Curriculum: Specialized medical sciences
1. Artificial intelligence and robotics in Interventional Radiolog
Curriculum: Specialized medical sciences
1. Use of respiratory function tests for diagnosis and follow-up of patients with Covid-19. 2. Differential effects of hypoglycemic therapies on survival in diabetic patients with COVID 19. 3. Evaluation of acute respiratory failure in patients with type 1 respiratory failure including Covid 19 patients.
Curriculum: Specialized medical sciences
1. Endocrine disorders in patients with common diseases (diabetes mellitus and/or obesity and/or hypertension) 2. Endocrine contributors to COVID-19
Requirements: Knowledge of endocrinology and metabolism, basic-level skills in next-generation sequencing techniques and statistics applied to biomedical research.
Curriculum: Specialized medical sciences
Bariatric-metabolic surgery as a model for studying nutritional ketosis
Curriculum: Specialized medical sciences
C. Conte
1. Clinical methodology (critical evaluation of choosing in medicine and scientific literature). 2. Risk stratification in cardiovascular diseases and in emergency situations, expecially in syncope.
Curriculum: Specialized medical sciences
Study of microcirculation:pathophysiologic and clinical implications.
Curriculum: Scienze mediche specialistiche
1. Immunopathogenesis of viral infections. 2. Role of the microbiome in MDR bacteria colonization. 3. Antimicrobial stewardship in medicine departments: role in the control of nosocomial infections. 4. Clinical and immunopathogenetic correlates of the disease caused by SARS-CoV-2 (Covid-19).
Curriculum: Specialized medical sciences
Modulation of the metabolism of the malignancies through the use of metformina and fast mimicking diet
Curriculum: Specialized medical sciences
1. Nasal Function 2. Sleep disorders in ENT 3. Olfactory impairment in SARS-Cov-2 infection 4. Central nervous involvement in SARS-Cov-2 infection
Curriculum: Specialized medical sciences
Biological and imaging markers for differential diagnosis and prognosis of neurodegenerative and demyelinating diseases of the central nervous system
Curriculum: Specialized medical sciences
1. Physiopathological mechanisms of insulin-resistance in obesity and diabetes. 2. Implications for atherosclerosis acceleration and microvascular complications. 3. Differential effects of hypoglycemic therapies on survival in diabetic patients with COVID 19
Curriculum: Specialized medical sciences
1. Hepatic steatosis and its cardiovascular complications as co-morbidities in different clinical settings (diabetes, viral infections, IBD, liver transplantation). 2. Bidirectional relationship between hepatic steatosis and altered body composition (obesity, sarcopenia and sarcopenic obesity).
Curriculum: Specialized medical sciences
Epidemiology, neurophysiology, clinical assessment and treatment of psychotic disorders.
Curriculum: Specialized medical sciences
Clinico-pathological characterization of the effects of specific therapies on the bone marrow, for the treatment of patients with MielodisplaticMieloproliferative syndromes.
Curriculum: Specialized medical sciences
1. Custom-made maxillary and mandibular reconstructions prior to implant surgery and maxillofacial oncologic surgery. 2. Sars-CoV-2 and other viral infections in HNSCC: genetic and epigenetic susceptibility characterization and related patient clinical profiles 3. Customized three-dimensional synthesis means in orthognathic surgery and in OSAS maxillofacial surgery; evaluation of splintless planning accuracy
Curriculum: Specialized medical sciences
Role of the autologous adipose tissue in tissue regeneration, in fibrosis reduction and in scar-pain control.
Curriculum: Specialized medical sciences
Retinal and choroidal disorders
Curriculum: Specialized medical sciences
Immunotherapy in head and neck tumours.
Curriculum: Specialized medical sciences
1. Development of personalized therapies in tumors of the nervous system. 2. New knowledge and surgical therapies in movement disorders.
Curriculum: Specialized medical sciences
1. Use of transcranic electromagnetic stimulation for the treatment of the endocrino-metabolic diseases. 2. Olfactory alterations and diabetes: early biomarker for disease complications
Curriculum: Specialized medical sciences
1. Cutaneous manifestations in patients with COVID-19: clinical, histopathological and immunological study based on an Italian registry 2. Comparison between classical and syndromic HS: a genetic and immunological study
Curriculum: Specialized medical sciences
1. Urothelial cancer: new diagnostic and therapeutic approaches 2. Translational analysis of the impact of HLA-G-related tolerance in overall health in infertile vs. fertile men. 3. Rare urological malignancies: penile and testicular cancer. Risk factors and predictors of lymph nodal and advanced disease analysis to develop personalized treatments.
Curriculum: Specialized medical sciences
Assessment and modulation of autonomic nervous system in acute and chronic diseases
Curriculum: Specialized medical sciences
1. Pathophysiology, clinics and personalized therapeutic strategies in myelodisplastic syndrom and myelodisplastic/myeloproliferative disorders. 2. Allogeneic transplantation of hemopoietic stem-cells and cell therapy in onco-hematology. 3. Detection of SARS-CoV-2-specific humoral and cellular immunity in patients affected by non-Hematologic and Hematologic Malignancies following recovery from COVID19
Curriculum: Specialized medical sciences
1. Pathophysiology, diagnosis and therapy of esophageal diseases. - 2. Endoscopic treatment of biliar diseases, especially of the biliar complications after liver transplantation.
Curriculum: Specialized medical sciences
1. Recurrent infective-inflammatory disease of the upper airways. 2. Mini-invasive surgery for airways obstructions. 3. Clinical expressions and relapse in ENT of the COVID-19 pandemic. 4. Biologic treatments for chronic rhinosinusitis with nasal polyps. 5. The role of nasal microbiota in pediatric upper airway infections
Curriculum: Specialized medical sciences
1. Assessment of structure/funcion relationship in glaucomatous damage 2. Efficacy of neuropritection in slowing glaucoma progressio 3. Evaluation of the role of inflammation in retinitis pigmentosa: therapeutic implications 4. Evaluation of the ocular surface in the elderly: comparison of different molecules in restoring lacrimal film
Curriculum: Specialized medical sciences
1. HIV infection: clinical, metabolic and pharmacological correlates and focus on genotypic and phenotypic resistance. 2. In vitro pharmacological response of SARS-CoV-2 to different drug classes with a different mechanism of action
Curriculum: Specialized medical sciences
1. Setup of a national database for the functional, respiratory and clinical characterization in a wide population of patients suffering from cronic obstructive broncho-pulmonary disease. 2. Gas exchange and morphological evaluation in COVID19 respiratory system: from acute to follow-up time.
Curriculum: Specialized medical sciences
Novel biomarkers of cardiovascular risk associated with adipose tissue plasticity in obese and/or diabetic subjects
Curriculum: Specialized medical sciences
Autonomic nervous system from bench to bedside: physiopathological and clinical aspects and new therapeutic approaches using vagal stimulation.
Curriculum: Specialized medical sciences
1. Morphological and functional adaptation of right ventricle at different stages of pulmonary circulation involvement in heart failure patients with reduced ejection fraction 2. Risk stratification in cardiovascular diseases and in emergency situations, expecially in syncope
Curriculum: Specialized medical sciences
New pathophysiological knowledge for the design of endovascular treatment of thoracic and abdominal aorta diseases.
Curriculum: Specialized medical sciences
1. Safety and efficacy of the Thulium laser system for endoscopic therapy of gastrointestinal lesions: a multicenter study. 2. Novel biomarkers for complicated and non-responsive celiac disease. 3. Nutritional status as a prognostic index in patients with Inflammatory Bowel Disease or Short Bowel Syndrome: evaluation of therapeutic strategies.
Curriculum: Specialized medical sciences
1. Ocular surface pathophysiology, clinics and therapeutic strategies 2. The eye as a window on the immune system
Curriculum: Specialized medical sciences
1. Effects of biophysical stimolation on musculo-skeletal tissues. Experimental study on the osteo-reparative response in the Zebra Fish. 2. Evaluation of transendothelial migration of monocytes in joints of obese patients with osteoarthrosis: prospective randomized clinical study.
Curriculum: Specialized medical sciences
Diagnostic, interventional and quantitative radiology of the musculoskeletal system.
Curriculum: Specialized medical sciences
Study of the progression of reticular drusen.
Curriculum: Specialized medical sciences
The complications in clinical trial: management and medical liability
Curriculum: Specialized medical sciences

Courses list

October 2021
Courses or activities Professor(s) ECTS Total hours Language
Optional
Updates in clinical and experimental Endocrinology, third series 4 20 Italian
November 2021
Courses or activities Professor(s) ECTS Total hours Language
Optional
Research Methodology in Clinical Research 5 26 Italian
December 2021
Courses or activities Professor(s) ECTS Total hours Language
Optional
Update on respiratory diseases 2 10 Italian
January 2022
Courses or activities Professor(s) ECTS Total hours Language
Optional
Cutaneous Lymphomas
10 66 Italian
February 2022
Courses or activities Professor(s) ECTS Total hours Language
Optional
Advanced course on pericardial disases 2 12 Italian
Pandora Evolution in Infectious Diseases Management 2020 2 12 Italian
Pathogenesis of epilepsy 5 42 English
March 2022
Courses or activities Professor(s) ECTS Total hours Language
Compulsory
From basic statistics to Big Data: an approach to Personalized Medicine 4 20 Italian
Optional
Systematic Reviews and Meta-analyses in Clinical research 3 16 Italian
Treatment of respiratory symptoms related to pathologic gastroesophageal reflux disease 2 10 Italian
April 2022
Courses or activities Professor(s) ECTS Total hours Language
Optional
Prognosis in non-oncologic patients wih advanced disease 2 10 Italian
The architecture and interpretation of diagnostic studies 2 10 Italian

Enrollment

Places available: 11

Call for applications

Please refer to the call for admission test dates and contents, and how to register.

Session: 1

Application for admission: from 20/07/2021 to 01/09/2021

Application for matriculation: from 29/09/2021 to 04/10/2021

Read the Call


Attachments and documents

Attachments to the call

Qualifications assessment

Evaluation Results

Session: 2

Application for admission: from 15/10/2021 to 08/11/2021

Application for matriculation: from 18/11/2021 to 22/11/2021

Read the Call


Attachments and documents

Attachments to the call

Extension

Attachment 1

Qualifications assessment

Evaluation Results

Research lines assigned