Clinical Research
Doctoral programme (PhD)
A.Y. 2020/2021
Study area
Medicine and Healthcare
PhD Coordinator
Students will learn a correct research approach for studying the causes and the clinical-therapeutic management of diseases.
Specific objectives:
identify clinical issues and uncertainties in pathogenesis, diagnosis, prognosis and in therapeutic approaches in various diseases;
correctly apply different research methodologies (randomized trials, longitudinal, cross-sectional or transversal studies and case control studies);
identify and use biological and genetic markers for studying clinical syndromes, guiding diagnosis and assessing the clinical outcome of different pathologies;
develop critical skills to analyse and comment clinical research results published or presented at national and international conferences;
introduce students to independent clinical research methods and to the issues and critical points relating to ethics in clinical research.
The programme is entirely in English.
Specific objectives:
identify clinical issues and uncertainties in pathogenesis, diagnosis, prognosis and in therapeutic approaches in various diseases;
correctly apply different research methodologies (randomized trials, longitudinal, cross-sectional or transversal studies and case control studies);
identify and use biological and genetic markers for studying clinical syndromes, guiding diagnosis and assessing the clinical outcome of different pathologies;
develop critical skills to analyse and comment clinical research results published or presented at national and international conferences;
introduce students to independent clinical research methods and to the issues and critical points relating to ethics in clinical research.
The programme is entirely in English.
Classes of master's degree - Possono presentare domanda di partecipazione al concorso di ammissione al dottorato di ricerca coloro i quali siano in possesso di laurea magistrale LM-41 - Medicina e chirurgia, che, nell'anno accademico 2019/2020, inizieranno il loro ultimo anno di una scuola di specializzazione di area medica dell'Università degli Studi di Milano e laureati magistrali nella LM-41 - Medicina e chirurgia, e in possesso del diploma di specializzazione di area medica.
Possono inoltre presentare domanda di partecipazione i possessori di laurea magistrale in Odontoiatria e protesi dentaria (LM-46).
Possono inoltre presentare domanda di partecipazione i possessori di laurea magistrale in Odontoiatria e protesi dentaria (LM-46).
Dipartimento di Fisiopatologia medico-chirurgica e dei trapianti, Via F. Sforza, 35 - 20122 Milano
- Main offices
Dipartimento di Fisiopatologia medico-chirurgica e dei trapianti, Via F. Sforza, 35 - 20122 Milano - Degree course coordinator: Emilio Berti
[email protected] - Degree course website
http://www.dept.unimi.it/ecm/home/didattica/dottorati
| Title | Professor(s) |
|---|---|
| 1. Rare autoimmune diseases. 2. Rare skin tumours.
Curriculum: Specialized medical sciences |
|
| 1. Epidemiology, diagnostic pathways and therapy of protozoan diseases (malaria, leishmaniasis, Chagas disease) 2. Antimicrobial stewardship routes 3. Characterization of the serological response during COVID-19 infection 4. Therapeutic approaches in patients with severe SARS-COV-2 disease 5. Identification of unfavorable outcome determinants in subjects with COVID-19 infection
Curriculum: Specialized medical sciences |
|
| 1. Pathophysiology, therapy and complications of hypothalamic-pituitary diseases and hypogonadism. 2. Endocrine diseases and SARS-CoV2 infections: search for prognostic risk factors and disease severity.
Curriculum: Specialized medical sciences |
|
| Morphological and functional adaptation of right ventricle ad different stages of pulmonary circulation involvement in heart failure patients with reduced ejection fraction
Curriculum: Specialized medical sciences |
|
| 1. Diseases of the pericardium. 2. Pregnancy in autoimmune diseases. 3. COVID 19: development of multi-arm clinical trials with immunotherapy. 4. COVID 19: hospitalization data analysis and epidemiological and clinical research. 5. VASCULITIS: pathogenesis, diagnosis, therapy, folow-up. 6. Fragile non-oncological patient in advanced disease phase: prognostic score.
Curriculum: Specialized medical sciences |
|
| 1. Neurodevelopmental disorders and epilepsy 2. Central nervous involvement in SARS-Cov-2 infection
Curriculum: Specialized medical sciences |
|
| 1. Image-guided percutaneous thermal ablation in the treatment of malignant and benign tumors. 2. Artificial intelligence: applications in interventional radiology
Curriculum: Specialized medical sciences |
|
| 1. Use of respiratory function tests for diagnosis and follow-up of patients with Covid-19. 2. Differential effects of hypoglycemic therapies on survival in diabetic patients with COVID 19.
Curriculum: Specialized medical sciences |
|
| 1. Endocrine disorders in patients with common diseases (diabetes mellitus and/or obesity and/or hypertension) 2. Endocrine contributors to COVID-19
Requirements: Knowledge of endocrinology and metabolism, basic-level skills in next-generation sequencing techniques and statistics applied to biomedical research. Curriculum: Specialized medical sciences |
|
| 1. Clinical methodology (critical evaluation of choosing in medicine and scientific literature). 2. Risk stratification in cardiovascular diseases and in emergency situations, expecially in syncope.
Curriculum: Specialized medical sciences |
|
| Study of microcirculation: pathophysiologic and clinical implications.
Curriculum: Specialized medical sciences |
|
| 1. Immunopathogenesis of viral infections. 2. Role of the microbiome in MDR bacteria colonization. 3. Antimicrobial stewardship in medicine departments: role in the control of nosocomial infections. 4. Clinical and immunopathogenetic correlates of the disease caused by SARS-CoV-2 (Covid-19).
Curriculum: Specialized medical sciences |
A. D'Arminio Monforte
|
| Modulation of the metabolism of the malignancies through the use of metformina and fast mimicking diet
Curriculum: Specialized medical sciences |
|
| 1. Physiopathological mechanisms of insulin-resistance in obesity and diabetes. 2. Implications for atherosclerosis acceleration and microvascular complications. 3. Differential effects of hypoglycemic therapies on survival in diabetic patients with COVID 19
Curriculum: Specialized medical sciences |
|
| 1. Metabolic and cardiovascular complications in non- alcoholic fatty liver disease (NAFLD) from adolescence to adults. 2. Role of metabolic alterations (non–alcoholic fatty liver disease (NAFLD)) and metabolic associated fatty liver disease (MAFLD)) in the clinical outcome of Sars-Cov-19 infection.
Curriculum: Specialized medical sciences |
|
| 1. The infection associated cryoglobulinemie: pathogenesis, genetic relates and therapy. 2. Virological, clinical and epidemiological studies on coronavirus infections and COVID. 3. Clinical, epidemiological and molecular studies on the plague.
Curriculum: Specialized medical sciences |
|
| Epidemiology, neurophysiology, clinical assessment and treatment of psychotic disorders.
Curriculum: Specialized medical sciences |
|
| Clinico-pathological characterization of the effects of specific therapies on the bone marrow, for the treatment of patients with Mielodisplatic Mieloproliferative syndromes.
Curriculum: Specialized medical sciences |
|
| Retinal and choroidal disorders
Curriculum: Specialized medical sciences |
|
| Immunotherapy in head and neck tumours
Curriculum: Specialized medical sciences |
|
| 1. Development of personalized therapies in tumors of the nervous system. 2. New knowledge and surgical therapies in movement disorders.
Curriculum: Specialized medical sciences |
|
| Use of transcranic electromagnetic stimulation for the treatment of the endocrino-metabolic diseases.
Curriculum: Specialized medical sciences |
|
| 1. Cutaneous manifestations in patients with COVID-19: clinical, histopathological and immunological study based on an Italian registry 2. Comparison between classical and syndromic HS: a genetic and immunological study
Curriculum: Specialized medical sciences |
|
| 1. Urothelial cancer: new diagnostic and therapeutic approaches 2. Translational analysis of the impact of HLA-G-related tolerance in overall health in infertile vs. fertile men. 3. Rare urological malignancies: penile and testicular cancer. Risk factors and predictors of lymph nodal and advanced disease analysis to develop personalized treatments.
Curriculum: Specialized medical sciences |
|
| Assessment and modulation of autonomic nervous system in acute and chronic diseases
Curriculum: Specialized medical sciences |
|
| 1. Pathophysiology, clinics and personalized therapeutic strategies in myelodisplastic syndrom and myelodisplastic/myeloproliferative disorders. 2. Allogeneic transplantation of hemopoietic stem-cells and cell therapy in onco-hematology. 3. Detection of SARS-CoV-2-specific humoral and cellular immunity in patients affected by non-Hematologic and Hematologic Malignancies following recovery from COVID19
Curriculum: Specialized medical sciences |
|
| 1. Pathophysiology, diagnosis and therapy of esophageal diseases. 2. Endoscopic treatment of biliar diseases, especially of the biliar complications after liver transplantation.
Curriculum: Specialized medical sciences |
R. Penagini
|
| 1. HIV infection: clinical, metabolic and pharmacological correlates and focus on genotypic and phenotypic resistance. 2. In vitro pharmacological response of SARS-CoV-2 to different drug classes with a different mechanism of action
Curriculum: Specialized medical sciences |
|
| 1. Setup of a national database for the functional, respiratoty and clinical characterization in a wide population of patients suffering from cronic obstructive broncho-pulmonary disease. 2. Gas exchange and morphological evaluation in COVID19 respiratory system: from acute to follow-up time.
Curriculum: Specialized medical sciences |
|
| Autonomic nervous system from bench to bedside: physiopathological and clinical aspects and new therapeutic approaches using vagal stimulation.
Curriculum: Specialized medical sciences |
|
| New pathophysiological knowledge for the design of endovascular treatment of thoracic and abdominal aorta diseases.
Curriculum: Specialized medical sciences |
|
| 1. Safety and efficacy of the Thulium laser system for endoscopic therapy of gastrointestinal lesions: a multicenter study. 2. Novel biomarkers for complicated and non-responsive celiac disease.
Curriculum: Specialized medical sciences |
|
| 1. Epileptic encephalopathies: clinics and traditional and innovative therapeutic approach. 2. Glucose transporter type 1 deficiency syndrome (Glut 1 disease): physiopathology, clinics and therapy.
Curriculum: Specialized medical sciences |
|
| 1. Ocular surface pathophysiology, clinics and therapeutic strategies 2. The eye as a window on the immune system
Curriculum: Specialized medical sciences |
|
| 1. Evaluation of homologous nerve grafts in the reconstruction of the nerves of the oral cavity. 2. Study of the effectiveness of facial nerve neurorrhaphy in the term-terminal and termino-lateral modalities.
Curriculum: Stomatology |
|
| Radioprotection in medicine concerning diagnosis treatment and therapy. Risks and benefits evaluation regarding patient characteristics.
Curriculum: Stomatology |
M.C. Cantone
|
| 1. Comparative mapping of viroma and microbiome of the upper respiratory tract in SARS-CoV-2 patients; 2. Development of an integrated proteomic and metabolomic approach for the treatment of SARS-CoV-2 patients admitted to intensive and subintensive therapies.
Curriculum: Stomatology |
|
| 1. Development and clinical application of new collagen xenogenous matrices for the regeneration of intra-oral soft tissues; 2. Development and clinical applications of customized Cad/cam titanium meshes for guided bone regeneration of atrophic edentulous jaws.
Curriculum: Stomatology |
|
| Autologous dentin matrix and platelet concentrates for alveolar site preservation and bone defects reconstruction procedures in oral surgery
Curriculum: Stomatology |
|
| 1. Morphofunctional analyses of organs and tissues of the oral system. 2. Nanotechnologies and nanomaterials to fight Covid-19 and viruses.
Curriculum: Stomatology |
|
| 1. Development of diagnostic, prognostic and therapeutic programmes using three-dimensional digital and radiographic images in dentistry. 2. Wearable saliva graphene biosensors in collaboration with Stanford University prof. Zhenan Bao 3. SarsCov-2 rapid salivary test detection 4. SarsCov-2 viral lipid-dependent attachment mouthwash inhibitor
Curriculum: Stomatology |
|
| 1. Nasal Function 2. Sleep disorders in ENT 3. Olfactory impairment in SARS-Cov-2 infection 4. Central nervous involvement in SARS-Cov-2 infection
Curriculum: Stomatology |
|
| Modern therapeutic approaches for periodontal and peri-implant diseases.
Curriculum: Stomatology |
|
| Biological and imaging markers for differential diagnosis and prognosis of neurodegenerative and demyelinating diseases of the central nervous system
Curriculum: Stomatology |
|
| 1. Custom-made maxillary and mandibular reconstructions prior to implant surgery and maxillofacial oncologic surgery. 2. Sars-CoV-2 and other viral infections in HNSCC: genetic and epigenetic susceptibility characterization and related patient clinical profiles 3. Customized three-dimensional synthesis means in orthognathic surgery and in OSAS maxillofacial surgery; evaluation of splintless planning accuracy
Curriculum: Stomatology |
|
| Role of the autologous adipose tissue in tissue regeneration, in fibrosis reduction and in scar-pain control.
Curriculum: Stomatology |
|
| Etiopathogenesis, diagnosis, treatment and prognosis of mucosal lesions with particular attention towards potentially malignant ones.
Curriculum: Stomatology |
|
| 1. Partial vs full thickness approach in implantology: PRS 2. Clinical evaluation of a resorbable meMbrane in GBR 3. Lifting and postural muscles behaviour in a group of classic dancers
Curriculum: Stomatology |
|
| 1. Study of the individual resistance determinants and environmental protective factors in Sars-CoV-2 infections in populations with low prevalence of infection. 2. Study of the adaptive immune response to Sars-CoV-2 infections in exposed and non-exposed populations (immunological response through cross-reactivity)
Curriculum: Stomatology |
|
| 1. New methodological and technological developments in physical and rehabilitation medicine 2. Verification of efficacy of therapies and reliability of outcome measurements in vertebral deformities
Curriculum: Stomatology |
|
| 1. Recurrent infective-inflammatory disease of the upper airways. 2. Mini-invasive surgery for airways obstructions. 3. Clinical expressions and relapse in ENT of the COVID-19 pandemic.
Curriculum: Stomatology |
|
| 1. Regeneration of Periodontal and peri-implant tissues, in particular surgical techniques, scaffolds and growth factors. 2. Development of 3D printed scaffolds for the regeneration of maxillary processes.
Curriculum: Stomatology |
|
| Single edentulism treatment through implant-supported rehabilitation with autologous connective or heterologous matrix graft. Multicentric, randomized controlled study.
Curriculum: Stomatology |
|
| 1. Effects of biophysical stimolation on musculo-skeletal tissues. Experimental study on the osteo-reparative response in the Zebra Fish. 2. Evaluation of transendothelial migration of monocytes in joints of obese patients with osteoarthrosis: prospective randomized clinical study.
Curriculum: Stomatology |
|
| Diagnostic, interventional and quantitative radiology of the musculoskeletal system.
Curriculum: Stomatology |
|
| Evaluation of molecules with anti-biofilm activity for the prevention and treatment of peri-implantitis.
Curriculum: Stomatology |
|
| Efficacy of laser biostimulation in pain and oedema reduction after impacted mandibular third molar extraction: multicentric, randomized study.
Curriculum: Stomatology |
|
| Study of the progression of reticular drusen.
Curriculum: Stomatology |
|
| The complications in clinical trial: management and medical liability.
Curriculum: Stomatology |
Courses list
November 2020
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Statistics Fundamentals and Research Methodology in Clinical Research | 5 | 28 | Italian | |
February 2021
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Biomaterials and Tissue Regeneration Techniques | 5 | 28 | Italian | |
| Updates in Cranio-Maxillofacial Sciences | Cantone Marie Claire
|
4 | 22 | Italian |
March 2021
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Oral Microbiology | 3 | 16 | Italian | |
| Systematic Reviews and Meta-Analyses in Clinical Research | 4 | 20 | Italian | |
November 2020
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Cutaneous Lymphomas | 10 | 66 | Italian | |
| Histological Diagnosis of Cutaneous Melanocytic Lesions | Gianotti Raffaele
|
10 | 50 | Italian |
| Pandora Evolution in Infectious Diseases Management 2020 | D'arminio Monforte Antonella
|
2 | 12 | Italian |
| Updates in Clinical and Experimental Endocrinology, Second Series | 3 | 18 | Italian | |
February 2021
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Advanced Course On Pericardial Disases | 2 | 12 | Italian | |
April 2021
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Prognosis in Non-Oncologic Patients Wih Advanced Disease | 2 | 10 | Italian | |
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