Molecular and Cellular Biology
Doctoral programme (PhD)
A.Y. 2023/2024
Study area
Science and Technology
PhD Coordinator
The doctoral programme aims to:
- train scientific experts with excellent skills in the field of biomolecular sciences and biotechnology;
- promote a molecular approach to the study of complex biological problems in model organisms (prokaryotic and eukaryotic microorganisms, animals and plants);
- encourage collaboration between research institutes, advanced training schools and companies in the fields of biomolecular sciences and biotechnology;
- encourage internationalisation by promoting international scientific collaborations, involving foreign lecturers, recruiting postgraduate students from abroad, and organising co-tutored dissertations involving study periods abroad.
Training activities will be characterised by:
- a multidisciplinary approach;
- interactivity;
- links to the business world;
- internationalisation.
A key element of the programme is the direct involvement of doctoral students in experimental research activities. Students will work full-time on a research project, providing critical insight and suggestions, and thereby acquiring scientific and organisational independence.
- train scientific experts with excellent skills in the field of biomolecular sciences and biotechnology;
- promote a molecular approach to the study of complex biological problems in model organisms (prokaryotic and eukaryotic microorganisms, animals and plants);
- encourage collaboration between research institutes, advanced training schools and companies in the fields of biomolecular sciences and biotechnology;
- encourage internationalisation by promoting international scientific collaborations, involving foreign lecturers, recruiting postgraduate students from abroad, and organising co-tutored dissertations involving study periods abroad.
Training activities will be characterised by:
- a multidisciplinary approach;
- interactivity;
- links to the business world;
- internationalisation.
A key element of the programme is the direct involvement of doctoral students in experimental research activities. Students will work full-time on a research project, providing critical insight and suggestions, and thereby acquiring scientific and organisational independence.
Classi di laurea - Classes of master's degrees:
LM-6 Biologia,
LM-7 Biotecnologie agrarie,
LM-8 Biotecnologie industriali,
LM-9 Biotecnologie mediche, veterinarie e farmaceutiche,
LM-11 Conservazione e restauro dei beni culturali,
LM-13 Farmacia e farmacia industriale,
LM-17 Fisica,
LM-18 Informatica,
LM-21 Ingegneria biomedica,
LM-22 Ingegneria chimica,
LM-25 Ingegneria dell'automazione,
LM-31 Ingegneria gestionale,
LM-32 Ingegneria informatica,
LM-35 Ingegneria per l'ambiente e il territorio,
LM-40 Matematica,
LM-41 Medicina e chirurgia,
LM-42 Medicina veterinaria,
LM-44 Modellistica matematico-fisica per l'ingegneria,
LM-46 Odontoiatria e protesi dentaria,
LM-47 Organizzazione e gestione dei servizi per lo sport e le attività motorie,
LM-48 Pianificazione territoriale urbanistica e ambientale,
LM-51 Psicologia,
LM-52 Relazioni internazionali,
LM-53 Scienza e ingegneria dei materiali,
LM-54 Scienze chimiche,
LM-56 Scienze dell'economia,
LM-58 Scienze dell'universo,
LM-59 Scienze della comunicazione pubblica, d'impresa e pubblicità,
LM-60 Scienze della natura,
LM-61 Scienze della nutrizione umana,
LM-67 Scienze e tecniche delle attività motorie preventive e adattate,
LM-68 Scienze e tecniche dello sport,
LM-69 Scienze e tecnologie agrarie,
LM-70 Scienze e tecnologie alimentari,
LM-71 Scienze e tecnologie della chimica industriale,
LM-73 Scienze e tecnologie forestali ed ambientali,
LM-74 Scienze e tecnologie geologiche,
LM-75 Scienze e tecnologie per l'ambiente e il territorio,
LM-76 Scienze economiche per l'ambiente e la cultura,
LM-78 Scienze filosofiche,
LM-79 Scienze geofisiche,
LM-82 Scienze statistiche,
LM-86 Scienze zootecniche e tecnologie animali,
LM-91 Tecniche e metodi per la società dell'informazione,
LM-92 Teorie della comunicazione,
LM/SNT1 Scienze infermieristiche e ostetriche,
LM/SNT2 Scienze riabilitative delle professioni sanitarie,
LM/SNT3 Scienze delle professioni sanitarie tecniche,
LM/SNT4 Scienze delle professioni sanitarie della prevenzione
LM-6 Biologia,
LM-7 Biotecnologie agrarie,
LM-8 Biotecnologie industriali,
LM-9 Biotecnologie mediche, veterinarie e farmaceutiche,
LM-11 Conservazione e restauro dei beni culturali,
LM-13 Farmacia e farmacia industriale,
LM-17 Fisica,
LM-18 Informatica,
LM-21 Ingegneria biomedica,
LM-22 Ingegneria chimica,
LM-25 Ingegneria dell'automazione,
LM-31 Ingegneria gestionale,
LM-32 Ingegneria informatica,
LM-35 Ingegneria per l'ambiente e il territorio,
LM-40 Matematica,
LM-41 Medicina e chirurgia,
LM-42 Medicina veterinaria,
LM-44 Modellistica matematico-fisica per l'ingegneria,
LM-46 Odontoiatria e protesi dentaria,
LM-47 Organizzazione e gestione dei servizi per lo sport e le attività motorie,
LM-48 Pianificazione territoriale urbanistica e ambientale,
LM-51 Psicologia,
LM-52 Relazioni internazionali,
LM-53 Scienza e ingegneria dei materiali,
LM-54 Scienze chimiche,
LM-56 Scienze dell'economia,
LM-58 Scienze dell'universo,
LM-59 Scienze della comunicazione pubblica, d'impresa e pubblicità,
LM-60 Scienze della natura,
LM-61 Scienze della nutrizione umana,
LM-67 Scienze e tecniche delle attività motorie preventive e adattate,
LM-68 Scienze e tecniche dello sport,
LM-69 Scienze e tecnologie agrarie,
LM-70 Scienze e tecnologie alimentari,
LM-71 Scienze e tecnologie della chimica industriale,
LM-73 Scienze e tecnologie forestali ed ambientali,
LM-74 Scienze e tecnologie geologiche,
LM-75 Scienze e tecnologie per l'ambiente e il territorio,
LM-76 Scienze economiche per l'ambiente e la cultura,
LM-78 Scienze filosofiche,
LM-79 Scienze geofisiche,
LM-82 Scienze statistiche,
LM-86 Scienze zootecniche e tecnologie animali,
LM-91 Tecniche e metodi per la società dell'informazione,
LM-92 Teorie della comunicazione,
LM/SNT1 Scienze infermieristiche e ostetriche,
LM/SNT2 Scienze riabilitative delle professioni sanitarie,
LM/SNT3 Scienze delle professioni sanitarie tecniche,
LM/SNT4 Scienze delle professioni sanitarie della prevenzione
Dipartimento di Bioscienze - Via Celoria, 26 - Milano
- Main offices
Dipartimento di Bioscienze - Via Celoria, 26 - Milano - Degree course coordinator: prof. Roberto Mantovani
[email protected] - Degree course website
https://bioscienzebio.unimi.it/phd_stud
| Title | Professor(s) |
|---|---|
| Mitochondrial dysfunction in atrial fibrillation pathogenesis
Requirements: Basic knowledge of general and cellular physiology |
|
| Interactome studies on regulators of flower development in rice through advanced proteomics
Requirements: Basic knowledge of plant anatomy, molecular biology, biochemistry and microsccopy |
|
| Translational regulation of the tumor microenvironment
Requirements: Basic knowledge of biochemistry, molecular and cellular biology |
|
| Development of new strategies for plant protection against phytopathogens
Requirements: Basic knowledge of plant physiology and optical microscopy |
|
| Elucidating key steps of Pseudomonas aeruginosa infection by lytic phages for phage therapy
Requirements: Basic knowledge of microbiology, genetics and molecular biology |
|
| Study of the recovery from Flavescence doreè in grapevine infected by Candidatus Phytoplasma vitis in vineyards excluded from re-infection by S.titanus
Requirements: R coding |
M. Moser (MACH)
|
| Study of the molecular mechanisms involved in cardiac rhythm disorders induced by inflammation
Requirements: Basic knowledge of general and cellular physiology |
|
| Development and application of in-silico techniques to simulate concentration dependent self-assembly processes at high spatial and time resolution
Requirements: Basic knowledge of structural biology, biophysics and coding |
|
| Looking at the role of microtubule dysfunction and RNA metabolism in pathological alpha-synuclein aggregation
Requirements: Basic knowledge of cellular and molecular biology |
|
| Flourish or perish: pro-regenerative epigenetic programme to sustain axonal sprouting of peripheral nerves
Requirements: Basic knowledge of cellular and molecular biology |
D. Cartelli (Besta)
|
| A human stem cell platform for the identification of modifiers of CAG repeat in the gene causing Huntington’s Disease
Requirements: Basic knowledge of genetics, molecular and cellular biology |
|
| Development and application of bioinformatics methods for the analysis, integration and interpretation of omics data
Requirements: Basic knowledge of genetics and molecular biology |
|
| Adaptation and resilience to climate change of the reproductive mechanisms in higher plants
Requirements: Basic knowledge of genetics, molecular biology and plant development. |
|
| Basic knowledge of genetics - dominance/epistasis - familiarity with the Crispr-Cas9 system
Requirements: Basic knoledge of genetics - dominance/epistasis - familiarity with the Crispr-Cas9 system |
|
| Study of the molecular mechanisms involved in the propagation of systemic electrical and calcium signals in response to mechanical stimuli in plants
Requirements: Basic knowledge of plant physiology, transport physiology, signal transduction, role of second messengers, optical microscopy. |
|
| Cellular and molecular characterization of the role of membrane glycoprotein, vasorin, on vascular musculature to investigate a possible link between chronic kidney disease and propensity to the onset of cardiovascular diseases.
Requirements: Basic knowledge of cell biology, animal/human cell cultures, cellular and protein biochemistry |
|
| Modeling SMPX-linked hearing loss and distal myopathy in zebrafish
Requirements: Basic knowledge of molecular biology, cell biology, and animal developmental biology |
|
| Investigation of alternative splicing dysregulation in tumors.
Requirements: Basic knowledge of genetics, molecular biology and bioinformarics |
|
| Biodiversity studies for adaptation to climate change tollerance in rice
Requirements: Basic knowledge of plant biology, botany and molecular biology |
|
| Defining novel molecular and cellular mechanisms that promote angiogenesis in neovascular diseases
Requirements: Basic knowledge of biochemistry, cellular and molecular biology and physiology |
|
| Study of the molecular mechanisms controlling cardiovascular regenerative cell function in age-associated diseases
Requirements: Basic knowledge of biochemistry, cellular and molecular biology and physiology |
G. Spinetti (Multimedica)
|
| Role of mechanical forces during the floral transition of the rice shoot apical meristem
Requirements: Basic knowledge of plant anatomy and molecular biology |
|
| Functional analysis of dependency-associated non-coding RNAs to discover novel vulnerabilities of human cancer (ex DM 118/2023)
Requirements: Basic knowledge in genetics, epigenetics, molecular and cell biology |
|
| Adapting flowering time and floral meristem commitment in response to temperature increase in Arabidopsis thaliana and Brassica napus for yield improvement
Requirements: Basic knowledge of genetics and molecular biology |
|
| Functional Analysis of Genes Controlling Inflorescence Architecture in Rice for Yield Improvement
Requirements: Basic knowledge of genetics and molecular biology |
|
| Molecular characterization of the role of single bacterial species from a multi-strain formulation marketed as probiotics on the virulence of clinical isolates from bacterial prostatitis (ex DM 117/2023)
Requirements: Basic knowledge of general and molecular microbiology |
|
| Dissecting the role of the FAM46C/BCCIP complex in multiple myeloma
Requirements: Experience working in a tissue colture hood would be a plus |
|
| Molecular basis of DNA-binding and molecular cooperativity of human Transcription Factors
Requirements: Basic knowledge of biochmistry, molecular biology and bioinformatics |
|
| Towards diagnostic fingerprinting using new optical biosensor technologies
Requirements: Basic knowledge of biochemistry, optical technologies and data handling |
|
| The potential of ncRNA as biomarkers of cardiovascular diseases (ex DM 117/2023)
Requirements: Basic knowledge of molecular biology and bioinformatics |
F. Martelli (PSD)
|
| The Flaviviruses replication complex as a strategic target for antivirals development
Requirements: Basic knowledge of biochemistry and strcutural biology |
E. Mastrangelo (CNR)
|
| Metformin administration combining with transcranial stimulation as a novel therapy against glioblastoma
Requirements: Basic knowledge of physics, biochemistry, cellular and molecular biology and physiology |
|
| High-throughput screening to identify Nfix-modulators in Cancer and Muscular Dystrophies
Requirements: Basic knowledge of cell and molecular biology |
|
| New hybrid Proteins: novel tools to regulate neuroinflammation in Multiple Sclerosis
Requirements: Basic knowledge of biochemistry and strcutural biology |
C. Milani (CNR)
|
| Characterization of the relationship between G-quadruplex, 3D nuclear organization, and genome stability (ex DM 118/2023)
Requirements: Basic knowledge of genetics and molecular biology |
|
| Novel therapeutic approaches emerging from ion channels' structural studies
Requirements: Basic knowledege of membrane proteins and rudiments of molecular biology, bicohemistry and biophysics |
|
| Cryo-EM structural biology on transcription factors and on their interaction with DNA
Requirements: Basic knowledge of biochemistry and structural biology |
|
| Functional and molecular characterization of the interaction between bacterial pathogens and tissue infiltrating Th17 cell subsets in chronic inflammatory diseases.
Requirements: Basic knowledge of Immunology, Microbiology and molecular biology. |
|
| Profiling transcription at DNA breaks to tackle genome instability
Requirements: Basic knowledge of genetics and molecular biology |
|
| Unravelling the function of chromatin remodellers in response to environmental stresses
Requirements: Basic knowledge in genetics, epigenetics, molecular and cell biology |
|
| Peptide-based fungicides for a sustainable agriculture
Requirements: Basic knowledge of Genetics, Molecular biology and Biochemistry |
|
| Role of flavonoids in the prevention of inflammation and related molecular mechanisms
Requirements: Basic knowledge of genetics and molecular biology |
|
| Manipulating the outer membrane permeability of Gram-negative bacteria as a strategy to develop of next generation antibacterial drugs (ex DM 118/2023)
Requirements: Basic knowledge of microbiology, bacterial genetics and molecular biology |
|
| Verso la comprensione del ruolo molecolare della N-glicosilazione nella aggregazione di catene leggere kappa in pazienti affetti da amiloidosi AL
Requirements: Basic knowledge of biochemistry and strcutural biology |
|
| Identification of novel bacterial virulence factors and inflammation determinants associated with persistent lung infections in cystic fibrosis patients
Requirements: Basic knowledge of general and molecular microbiology |
|
| Mechanism of action and (self)regulation of human MICAL1, the multidomain flavoenzyme involved in the control of actin cytoskleton dynamics in health and disease
Requirements: Basic knowlwedge of biochiemistry and molecula biology |
|
| Characterization of human histone (lysine) deacetylases as drug targets
Requirements: Basic knowlwedge of biochiemistry and molecula biology |
|
| A Drosophila model of Type B Kufs/CLN13 disease to study pathogenesis and Cathepsin F function
Requirements: Basic knowledge of cell and molecular biology |
|
| An in vivo model of intractable R257C-ACTG2 Visceral Myopathy to study pathogenesis and to identify new disease targets
Requirements: Basic knowledge of cell and molecular biology |
|
| Seed biology traits governed by heterosis and their relation to environmental stresses (ex DM 117/2023) | |
| Biochemical and structural characterisation of toxic protein aggregates from cats affected by AA amyloidosis to design future treatments (ex DM 117/2023) | |
| Epigenetic and metabolic targeting of skeletal muscle, during aging (ex DM 118/2023) |
Courses list
November 2023
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Protein Structure Prediction and Design: How to Use Alphafold and Other Ai Methods for Research | 2 | 12 | English | |
January 2024
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Compulsory | ||||
| Biostatistics for Molecular and Cellular Biology | 5 | 27 | English | |
February 2024
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Compulsory | ||||
| Molecular and Cellular Biology. Methods and Communication of Results | 4 | 24 | English | |
June 2024
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Big-Data in Molecular Biology: from Experimental Design to Molecular Function | 2 | 12 | English | |
July 2024
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Disease Modeling in Molecular Biomedicine: Focus On Excitable Systems | 2 | 12 | English | |
Enrolment
Places available: 21
Call for applications
Please refer to the call for admission test dates and contents, and how to register.
Application for admission: from 27/06/2023 to 26/07/2023
Application for matriculation: from 25/09/2023 to 01/10/2023
Attachments and documents
Following the programme of study
Contacts
Office and services for PhD students and companies