Experimental Medicine
Doctoral programme (PhD)
A.Y. 2026/2027
Study area
Medicine and Healthcare
PhD Coordinator
Experimental medicine develops and applies technology and biological models for studying pathogenic mechanisms in human disease. It involves various disciplines (biochemistry, biology, molecular biology, anatomy, physiology, pathology, immunology, genetics and microbiology/virology) that are providing a rapidly growing understanding of the mechanisms that enable the development of pathological processes. The course aims to acquaint students with the technologies and research methodologies in the area of biomedicine and biotechnology based on in vitro and in vivo experimental models and '-omic' approaches, and on their application to the study of cellular and molecular mechanisms involved in the pathogenesis of human disease. The final objective is the formation of high-level scientists able to combine an understanding of biological processes and pathogenic mechanisms through the application of advanced experimental techniques. The programme's specific objectives are:
1) develop the ability to define problems and devise experiments to solve them in accordance with scientific standards;
2) study biochemical, molecular and cellular mechanisms in physiopathology using advanced technologies;
3) develop the ability to critically assess scientific literature;
4) provide solid, up-to-date knowledge in the specific field;
5) teach how to conduct independent research, and inform on related ethical implications.
1) develop the ability to define problems and devise experiments to solve them in accordance with scientific standards;
2) study biochemical, molecular and cellular mechanisms in physiopathology using advanced technologies;
3) develop the ability to critically assess scientific literature;
4) provide solid, up-to-date knowledge in the specific field;
5) teach how to conduct independent research, and inform on related ethical implications.
Tutte le classi di laurea magistrale - All classes of master's degree
Dipartimento di Biotecnologie mediche e medicina traslazionale - Via L. Vanvitelli, 32 - 20129 Milano
- Degree course coordinator: Nicoletta Landsberger
[email protected] - Main offices
Dipartimento di Biotecnologie mediche e medicina traslazionale - Via L. Vanvitelli, 32 - 20129 Milano - Degree course website
http://d-memphd.unimi.it/
| Title | Professor(s) |
|---|---|
| Combined pharmacological approaches for neural tissue regeneration
Requirements: Any experience in molecular biology, biochemistry, cell culture, cell metabolism is an advantage. Motivated students with a strong commitment to basic and translational research are invited to apply. The candidate should have well-developed social skills, a hands-on attitude and be able to work in a team. |
|
| iFOLLICLE-3D: iPSC-DERIVED 3D-OVARIAN FOLLICLE GENERATION: IN VITRO OVARIAN DISEASE MODELLING
Requirements: The ideal candidate possesses a solid scientific background in female reproductive endocrinology, including knowledge of oogenesis and folliculogenesis, their physiology and related dysfunctions. Required laboratory expertise includes molecular and cellular biology, confocal microscopy, and data analysis using specialized software. Appropriate personal abilities for experimental PhD research are expected |
|
| Airway epithelial regulation of pulmonary immunity: from molecular mechanisms to therapeutic targets
Requirements: Knowledge of the main techniques of cellular, molecular biology and biochemistry (cell cultures, gene silencing, gene and protein expression analysis, lipid analyses, enzymatic assays). Availability of spending periods abroad for training and collaborations. |
|
| Co-culture of endothelial cells and osteoblasts in microgravity: effects on osteoblast activity
Requirements: Cell culture, Western Blotting, Nucleic acids extraction, Real-Time PCR, gene silencing. |
|
| Multi-level characterization of multiple myeloma to elucidate disease mechanisms and their potential relevance for patient outcomes
Requirements: Basic knowledge of cellular and molecular biology |
|
| Role of tumor thymic epithelial cells in tymoma-associated immune dysregulation
Requirements: Basic experience in cell culture techniques; basic experience in flow cytometry, molecular biology and related computational analytical approaches; willingness to spend periods abroad for training and collaborations |
|
| Dysfunctional skeletal muscle and nervous system in Duchenne muscular dystrophy: unraveling the role of Exocyst complex component 3-like protein 4
Requirements: The ideal candidate is highly motivated to study the molecular mechanisms underlying Duchenne muscular dystrophy, with a particular interest in the integration between muscle pathology and the central nervous system. A solid background in molecular and cellular biology is required, along with strong aptitude or working with murine models and for applying techniques for gene expression and functional analysis in cell culture system. |
|
| Analyzing the metabolism of brain cholesterol through spatial lipidomics and studying the therapeutic benefits of brain permeable cholesterol-loaded nanoparticles in Rett syndrome
Requirements: Knowledge of the fundamentals of neurobiology and animal experimentation |
|
| Natural History and Biomarker Discovery in BPAN (Beta-propeller protein-associated neurodegeneration) A Multicentre Clinical–Translational Study to Enable Precision Medicine
Requirements: Experience in clinical and molecular genetics related to movement disorders in children; experience in outcome meausres and assessment scales |
G. ZORZI (Besta)
|
| Role of Ms4a proteins in the regulation of macrophage functions in inflammatory and tumor contexts
Requirements: Basic cellular and molecular biology |
|
| Multi-omics analysis of the immune response and correlates of protection induced in humans by a nucleoprotein-targeted influenza vaccine
Requirements: The ideal candidate should have a backgroung in experimental immunology together with strong organizational skills. Prior experience in flow cytometry, cellular and molecular biology are requested. Strong communication skills, attention to detail, accuracy in laboratory, ability to work in multidisciplinary/collaborative environment are also requested |
|
| Targeting tumor-Escape mechaNIsms in patients with esophagoGastric adenocarcinoMA refractory to combined chemoimmunotherapy (ENIGMA)
Requirements: The ideal candidate should have a background in experimental immunology together with strong organizational skills. Prior experience in flow cytometry, cellular and molecular biology are requested. Strong communication skills, attention to detail, accuracy in laboratory, ability to work in multidisciplinary/collaborative environment are also requested. |
J. MIKULAK (Humanitas)
|
| Detection of pathological fingerprints in clinical and prodromal α-synucleinopathies through innovative non-invasive multi-biomarker analysis of blood, olfactory mucosa, and tears
Requirements: Background in neurodegenerative diseases, particularly in α-synucleinopathies and isolated REM sleep behavior disorder (iRBD). Knowledge of biomarker research relevant to neurodegenerative disorders. Basic understanding of molecular and biochemical techniques (e.g. seed amplification, nucleic acid analysis). Experience in handling and processing human samples (e.g. blood, olfactory mucosa). |
M. CATANIA (Besta)
|
| Decoding Drug Efficacy in Rett Syndrome through Integrative Computational and Experimental Approaches
Requirements: Experience in the field of experimental Molecular Biology/Neurosciences or similar fields. Experience in the area of biocomputing/scripting is considered a plus. |
|
| Mechanistic Dissection of Histone Lactylation in CD4⁺ Regulatory T Cells | |
| iPSC-derived thyroid organoid models to decipher the molecular architecture of congenital hypothyroidism (Orga-Thy)
Requirements: Documented experience on cell culture and general molecular biology techniques |
E. S. GRASSI (IRCCS Auxologico)
G. RURALE (IRCCS Auxologico)
|
| Novel therapeutic strategies targeting IGF2 autocrine proliferative loop in adrenocortical carcinoma (ACC): in vitro and in vivo studies
Requirements: Cell cultures; cell transfection and silencing; protein detection (western blot); nucleic acid extraction, PCR. |
|
| Molecular mechanisms regulating IGF2R pathway in adrenocortical carcinoma (ACC)
Requirements: Cell cultures; cell transfection and silencing; protein detection (western blot); nucleic acid extraction, PCR. |
|
| Inflammation Across Life: Mechanisms, Modulators, and Predictive Power
Requirements: Expertise in cellular and molecular biology. Preferred but not mandatory, experience in zebrafish and/or cellular models. |
|
| Heart-Brain axis implications in vulnerability to chronic stress
Requirements: The ideal candidate holds basic experience working in vivo with experimental preclinical models in particular knowledge with behavioral analyses and pharmacological treatments. In addition, good expertise in molecular biology approaches will be considered as a preferential qualification |
|
| Therapeutic approaches targeting TDP-43-proteinopathy in ALS
Requirements: Cell culture of iPSCs: reprogramming, maintenance, differentiation into neurons/motoneurons. Immunofluorescence, use of confocal microscope, image analysis. Western Blot. Real time PCR. |
P. BOSSOLASCO (IRCCS Auxologico)
|
| Role of IL-33 signaling in metabolic and inflammatory remodeling of the heart under high-fat diet conditions
Requirements: Molecular biology: DNA/RNA extraction, PCR, RT-PCR. Cell culture: 2D and 3D culture, cell viability assay. Histology: basic knowledge of histological techniques. Immunoenzymatic assays (ELISA) |
|
| New Frontiers in Neuroendocrine Tumors: The Zebrafish Model
Requirements: Strong interest in basic and translational research, preferably in oncology or related fields. Basic knowledge of molecular and cellular biology. Motivation, curiosity, and willingness to learn new experimental approaches. Ability to work in a collaborative research environment. |
G. GAUDENZI (IRCCS Auxologico)
|
Enrolment
Places available: 15
Call for applications
Please refer to the call for admission test dates and contents, and how to register.
Application for admission: from 11/05/2026 to 10/06/2026
Application for enrolment: from 06/07/2026 to 10/07/2026
Attachments and documents
Following the programme of study
Contacts
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