Pharmaceutical sciences

Dottorati
Doctoral programme (PhD)
A.Y. 2021/2022
Study area
Science and Technology
Doctoral programme (PhD)
3
Years
Dipartimento di Scienze farmaceutiche - Via Mangiagalli, 25 - Milano
English
PhD Coordinator
The doctoral programme is designed to train highly skilled doctors to work successfully in the industrial and academic fields, and in the sector of medicines and healthcare products. The training, which aims at providing advanced methodological knowledge and scientific content in the pharmaceutical sector, includes theory and research, both centred on the design, synthesis, development and control of new biologically active compounds, new pharmaceutical forms, special foods, cosmetics, biocides and medical devices, typical of the fields covered in the doctoral programme:

- Design and synthesis of biologically active compounds
- Pharmaceutical, biopharmaceutical and toxicological analysis
- Drug metabolism and pharmacokinetics
- Pharmaceutical technology and legislation
- Food chemistry and food supplements
- Fermentation chemistry and biotechnology
- Advanced synthetic methodologies
- Physico-chemical characterization of biologically active compounds
- Herbal drugs, botanicals and active ingredients of plant origin
- Statistical methods for experimental data processing
Classi di laurea magistrale - Classes of master's degree:
LM-6 Biologia,
LM-8 Biotecnologie industriali,
LM-9 Biotecnologie mediche, veterinarie e farmaceutiche,
LM-13 Farmacia e farmacia industriale,
LM-21 Ingegneria biomedica
LM-22 Ingegneria chimica,
LM-53 Scienza e ingegneria dei materiali,
LM-54 Scienze chimiche,
LM-61 Scienze della nutrizione umana,
LM-69 Scienze e tecnologie agrarie,
LM-70 Scienze e tecnologie alimentari,
LM-71 Scienze e tecnologie della chimica industriale.
Dipartimento di Scienze farmaceutiche - Via Mangiagalli, 25 - Milano
Title Professor(s)
Plants, ethnobotanical, natural products and food: from characterization to application
F. Secundo
Design of films for drug administration
Study of novel micro- and nanoparticulates drug delivery systems
F. Secundo
Study and development of oral drug delivery systems for spatio-temporal control of release
Study and development of therapeutic systems for intra-vesical release of drugs
Design and synthesis of non-natural amino acids, peptidomimetics and their exploitation for the preparation of complex molecular architectures finding applications in biology, chemistry and nanomaterials
C-C and C-H bonds activation through the metal-catalysis as a sustainable process to access to bioactive heterocyclic systems
S. Riva
Development and application of computational approaches for rational design of novel biologically active compounds, for the investigation of their mechanism of action and for the prediction of their ADME/Tox profile
Application of analytical, bioanalytical and "omics" techniques in drug discovery and development (identification of disease targets and biomarkers; study of the biological effects of drug candidates and drug metabolism)
M. Chiari
Design, synthesis and study of structure-activity relationships of new derivatives acting at G protein-coupled receptors or at ligand-operated ionic channels
Design, synthesis, structural and biological characterization and SAR of compounds with antiproliferative or antimicrobial activity
Stereotechnologies development in the preparation and characterization of chiral molecules of biological concern
S. Riva
F. Secundo
Quantitative and functional proteomic in drug discovery and development
Synthesis and chemical-physical characterization of nucleic acids analogues, including Peptide Nucleic Acids (PNAs), and aggregates with applications in biology and/or in nanomaterials.
Protein hydrolysates and biopeptides: production, biological activities, and their applications in biomedical, food and cosmetic areas.
F. Secundo
New chemotypes from natural substances: design, synthesis and biological characterization.
S. Riva
Biologically active lipids in drug discovery and development
F. Secundo
Novel applied experimental models for the development of new therapeutic approaches in cardiovascular and pulmonary disease
Development of novel multitarget compounds with anti-inflammatory activity and improved safety profile
Repurposing of anti-inflammatory drugs
Phage display and fusion antibodies approaches to screen new molecular targets in the treatment of human pandemic infections and new barrer penetrating enhancers.
Hydrogels and biocompatible polymers for tissue regeneration and tumor resection
Diagnostic labels
M. Chiari
Hybrid materials for the delivery of biomolecules
Chemical Synthesis and biochemical characterization of protein domains involved in neurodegenerative diseases
Development of nanomaterials for the cryoconservation of tissues and organs
Design, synthesis and pharmacological investigation of light-regulated bioactive compounds.
Development of click chemistry hydrogels with applications in biosensing
M. Chiari
Self-assembly and chemical reactions in vitro and in vivo

Courses list

January 2022
Courses or activities Professor(s) ECTS Total hours Language
Optional
Application of peptides and proteins in pharmaceutical sciences 5 25 English
February 2022
Courses or activities Professor(s) ECTS Total hours Language
Compulsory
The drug discovery process: development of a clinical candidate 4 20 English
April 2022
Courses or activities Professor(s) ECTS Total hours Language
Optional
HPC@UNIMI: INDACO for chemoinformatic and biophysical approaches in drug discovery 2 10 English
May 2022
Courses or activities Professor(s) ECTS Total hours Language
Optional
Biocatalytic approaches to the synthesis of enantiopure drugs substances 2 10 English
September 2022
Courses or activities Professor(s) ECTS Total hours Language
Optional
Basic statistics for biological data 2 10 English
Mass spectrometry applications in drug discovery 3 15 English

Enrollment

Places available: 16

Call for applications

Please refer to the call for admission test dates and contents, and how to register.

Session: 1

Application for admission: from 28/06/2021 to 01/09/2021

Application for matriculation: from 27/09/2021 to 02/10/2021

Read the Call


Attachments and documents

Attachments to the call

Qualifications assessment

Evaluation Results

Extension

Session: 2

Application for admission: from 15/10/2021 to 08/11/2021

Application for matriculation: from 18/11/2021 to 22/11/2021

Read the Call


Attachments and documents

Attachments to the call

Extension

Attachment 1

Qualifications assessment

Evaluation Results

Assignment research lines