Molecular and Cellular Biology
Doctoral programme (PhD)
A.Y. 2022/2023
Study area
Science and Technology
PhD Coordinator
The doctoral programme aims to:
- train scientific experts with excellent skills in the field of biomolecular sciences and biotechnology;
- promote a molecular approach to the study of complex biological problems in model organisms (prokaryotic and eukaryotic microorganisms, animals and plants);
- encourage collaboration between research institutes, advanced training schools and companies in the fields of biomolecular sciences and biotechnology;
- encourage internationalisation by promoting international scientific collaborations, involving foreign lecturers, recruiting postgraduate students from abroad, and organising co-tutored dissertations involving study periods abroad.
Training activities will be characterised by:
- a multidisciplinary approach;
- interactivity;
- links to the business world;
- internationalisation.
A key element of the programme is the direct involvement of doctoral students in experimental research activities. Students will work full-time on a research project, providing critical insight and suggestions, and thereby acquiring scientific and organisational independence.
- train scientific experts with excellent skills in the field of biomolecular sciences and biotechnology;
- promote a molecular approach to the study of complex biological problems in model organisms (prokaryotic and eukaryotic microorganisms, animals and plants);
- encourage collaboration between research institutes, advanced training schools and companies in the fields of biomolecular sciences and biotechnology;
- encourage internationalisation by promoting international scientific collaborations, involving foreign lecturers, recruiting postgraduate students from abroad, and organising co-tutored dissertations involving study periods abroad.
Training activities will be characterised by:
- a multidisciplinary approach;
- interactivity;
- links to the business world;
- internationalisation.
A key element of the programme is the direct involvement of doctoral students in experimental research activities. Students will work full-time on a research project, providing critical insight and suggestions, and thereby acquiring scientific and organisational independence.
Classi di laurea - Classes of master's degrees:
LM-6 Biologia,
LM-7 Biotecnologie agrarie,
LM-8 Biotecnologie industriali,
LM-9 Biotecnologie mediche, veterinarie e farmaceutiche,
LM-11 Conservazione e restauro dei beni culturali,
LM-13 Farmacia e farmacia industriale,
LM-17 Fisica,
LM-18 Informatica,
LM-21 Ingegneria biomedica,
LM-22 Ingegneria chimica,
LM-25 Ingegneria dell'automazione,
LM-31 Ingegneria gestionale,
LM-32 Ingegneria informatica,
LM-35 Ingegneria per l'ambiente e il territorio,
LM-40 Matematica,
LM-41 Medicina e chirurgia,
LM-42 Medicina veterinaria,
LM-44 Modellistica matematico-fisica per l'ingegneria,
LM-46 Odontoiatria e protesi dentaria,
LM-47 Organizzazione e gestione dei servizi per lo sport e le attività motorie,
LM-48 Pianificazione territoriale urbanistica e ambientale,
LM-51 Psicologia,
LM-52 Relazioni internazionali,
LM-53 Scienza e ingegneria dei materiali,
LM-54 Scienze chimiche,
LM-56 Scienze dell'economia,
LM-58 Scienze dell'universo,
LM-59 Scienze della comunicazione pubblica, d'impresa e pubblicità,
LM-60 Scienze della natura,
LM-61 Scienze della nutrizione umana,
LM-67 Scienze e tecniche delle attività motorie preventive e adattate,
LM-68 Scienze e tecniche dello sport,
LM-69 Scienze e tecnologie agrarie,
LM-70 Scienze e tecnologie alimentari,
LM-71 Scienze e tecnologie della chimica industriale,
LM-73 Scienze e tecnologie forestali ed ambientali,
LM-74 Scienze e tecnologie geologiche,
LM-75 Scienze e tecnologie per l'ambiente e il territorio,
LM-76 Scienze economiche per l'ambiente e la cultura,
LM-78 Scienze filosofiche,
LM-79 Scienze geofisiche,
LM-82 Scienze statistiche,
LM-86 Scienze zootecniche e tecnologie animali,
LM-91 Tecniche e metodi per la società dell'informazione,
LM-92 Teorie della comunicazione,
LM/SNT1 Scienze infermieristiche e ostetriche,
LM/SNT2 Scienze riabilitative delle professioni sanitarie,
LM/SNT3 Scienze delle professioni sanitarie tecniche,
LM/SNT4 Scienze delle professioni sanitarie della prevenzione
LM-6 Biologia,
LM-7 Biotecnologie agrarie,
LM-8 Biotecnologie industriali,
LM-9 Biotecnologie mediche, veterinarie e farmaceutiche,
LM-11 Conservazione e restauro dei beni culturali,
LM-13 Farmacia e farmacia industriale,
LM-17 Fisica,
LM-18 Informatica,
LM-21 Ingegneria biomedica,
LM-22 Ingegneria chimica,
LM-25 Ingegneria dell'automazione,
LM-31 Ingegneria gestionale,
LM-32 Ingegneria informatica,
LM-35 Ingegneria per l'ambiente e il territorio,
LM-40 Matematica,
LM-41 Medicina e chirurgia,
LM-42 Medicina veterinaria,
LM-44 Modellistica matematico-fisica per l'ingegneria,
LM-46 Odontoiatria e protesi dentaria,
LM-47 Organizzazione e gestione dei servizi per lo sport e le attività motorie,
LM-48 Pianificazione territoriale urbanistica e ambientale,
LM-51 Psicologia,
LM-52 Relazioni internazionali,
LM-53 Scienza e ingegneria dei materiali,
LM-54 Scienze chimiche,
LM-56 Scienze dell'economia,
LM-58 Scienze dell'universo,
LM-59 Scienze della comunicazione pubblica, d'impresa e pubblicità,
LM-60 Scienze della natura,
LM-61 Scienze della nutrizione umana,
LM-67 Scienze e tecniche delle attività motorie preventive e adattate,
LM-68 Scienze e tecniche dello sport,
LM-69 Scienze e tecnologie agrarie,
LM-70 Scienze e tecnologie alimentari,
LM-71 Scienze e tecnologie della chimica industriale,
LM-73 Scienze e tecnologie forestali ed ambientali,
LM-74 Scienze e tecnologie geologiche,
LM-75 Scienze e tecnologie per l'ambiente e il territorio,
LM-76 Scienze economiche per l'ambiente e la cultura,
LM-78 Scienze filosofiche,
LM-79 Scienze geofisiche,
LM-82 Scienze statistiche,
LM-86 Scienze zootecniche e tecnologie animali,
LM-91 Tecniche e metodi per la società dell'informazione,
LM-92 Teorie della comunicazione,
LM/SNT1 Scienze infermieristiche e ostetriche,
LM/SNT2 Scienze riabilitative delle professioni sanitarie,
LM/SNT3 Scienze delle professioni sanitarie tecniche,
LM/SNT4 Scienze delle professioni sanitarie della prevenzione
Dipartimento di Bioscienze - Via Celoria, 26 - Milano
- Main offices
Dipartimento di Bioscienze - Via Celoria, 26 - Milano - Degree course coordinator: prof. Roberto Mantovani
[email protected] - Degree course website
https://bioscienzebio.unimi.it/phd_stud
| Title | Professor(s) |
|---|---|
| Manipulation of caveolin expression levels to improve membrane fragility in caveolinopathies and muscular dystrophies to prevent myocytes lost and the onset of arrhythmias | |
| Biochemistry and molecular mechanisms of florigenic signal transduction from rice leaves to shoot apical meristems via innovative proteomic approaches and imaging techniques. | |
| Translational control of T cell-tumor interaction | |
| T cell polarization in the tumor microenvironment | |
| Dissecting Transposable Elements transcription in human T lymphocytes in health and disease | |
| Study of the role of plant Ca2 + transporters in the regulation of the Ca2 + signature generated in response to environmental stresses through in vitro biochemical and structural analyzes and molecular imaging | |
| Biology of model phages for phage therapy against P.aeruginosa | |
| Bacterial and parasite -omics, mathematical modelling of biological systems with particular attention to their evolution. | |
| Inflammation and cardiac rhythm disorders | |
| Computational structural biology of protien folding, misfolding and aggregation | |
| Pathogenic mechanisms in neurodegeneration: interplay among microtubule cytoskeleton, RNA metabolism and protein aggregation. | |
| Dissecting the role of the methylase SMYD3 in the modulation of different features of breast cancer stem cells, and its impact on metastasis formation in vivo. | |
| Human stem cell-based approaches for the study of transcriptional and chromatin abnormalities of Huntington’s disease neurons | |
| Identifying the cell-specific neurodevelopmental component of Huntington Disease in the striatum using combined single-cell RNA and ATAC sequencing | |
| Identifying the cell-specific neurodevelopmental component of Huntington Disease in the cortex using combined single-cell RNA and ATAC sequencing | |
| Development and application of bioinformatics tools and methods for the analysis, integration and interpretation of omics data in precision medicine | |
| Food security: Innovative plant reproductive strategy in a chancing environmental condition. | |
| Study of the role of second messengers in the perception and response of plants to environmental stresses using state of the art microscopy and genetically encoded biosensors. | |
| Cellular and molecular effects of uremic toxins on the microvascular endothelium and its secretoma as well as on the absorbent intestinal epithelium. Characterization of the plasma proteome of patients with chronic kidney disease (CKD). | |
| From cancer to neurodegeneration: zebrafish to investigate human diseases | |
| Investigation of alternative splicing dysregulation in tumors. | |
| Uncovering molecular regulators as well as signalling cascades involved in intercompartmental comunication that control seed development | |
| Defining novel molecular and cellular mechanisms that promote angiogenesis in neovascular diseases | |
| Molecular mechanisms controlling the growth of rice in response to environmental and hormonal stimuli | |
| Functional dissection of the canonical and non-canonical interplay between noncoding RNAs and NFY transcription factor in human cancer | |
| Genetic diversity, evolution and functional impact of structurally complex loci of the human genome associated with neurodevelopmental disorders | |
| Molecular bases of DNA-binding and functional cooperativity of human Transcription Factors | |
| Structure and functional studies of self-assembling multi-enzyme nanoparticles for continuous redox biocatalysis. | |
| development and implementation of bioinformatics tools for genomics and transcriptomics | |
| Functional Analysis of Genes Controlling Inflorescence Architecture in Arabidopsis and Rice | |
| Regulation of gene expression linked to virulence and interaction with the host in model bacteria. | |
| Studies on the role of alternative splicing isoforms in human tumors | |
| Identification of new diagnostic and therapeutic strategies to counteract the expansion of cerebral tumors, particularly glioblastoma | |
| Development of a liposome-based and nutrigenomic approach to silence the transcription factor Nfix in Muscular Dystrophy | |
| Innovative medical treatments based on the understanding of ion channel gating principles | |
| Studying the molecular mechanisms responsible for the maintenance of genome integrity and their connections to human pathologies | |
| Integrated structural biology on transcription factors | |
| Functional and molecular characterization of the interaction between pathogens and tissue infiltrating Th1/17 cells in chronic inflammatory diseases. | |
| Development and application of bioinformatic methods for the genome-wide characterization of gene expression and its regulation | |
| Profiling transcription at DNA breaks to tackle genome instability | |
| Unravelling the role of chromatin remodellers in response to environmental stimuli | |
| Protective role of anthocyanins in cell model systems and dietary treatments in mice | |
| Breaking Gram-negative bacteria outer membrane permeability barrier as a strategy to develop next generation antibacterial drugs | |
| The lysosomal amyloid aggregation of β2-microglobulin promotes Multiple myeloma progression: a molecular focus on this pro-cancer mechanism | |
| Investigation on the role and extent of translational control in diseases as diverse as autoimmune and neurological disorders. | |
| Study of smooth muscle functionality in clinically-relevant Drosophila melanogaster models of a rare visceral myopathy caused by the R257C mutation in actin G2 | |
| Development and implementation of cloud-oriented bioinformatic tools and workflows | |
| Structural study of proteins involved in different human diseases: retromer complex (ALS); CD36 (cancer); chimeric protein engineered for gene therapy (MS) |
Mario Milani (CNR)
|
| Structural and functional characterization of proteins involved in human pathologies for drug design and development, maily: 1) RNA virus proteins; 2) pro-apoptotic protein complexes overexpressed in tumors |
Eloise Mastrangelo (CNR)
|
| Alpha-synuclein aggregation: modulators and impact on gut-brain axis (Ex DM 352/2022) | |
| Large-scale druggability assessment of target libraries with artificial intelligence-based structure-sequence combined features |
Eloise Mastrangelo (CNR)
|
| Large-scale druggability assessment of target libraries with artificial intelligence-based structure-sequence combined features (Ex DM 352/2022) | |
| Translational regulation of gene expression | |
| New state-of-the-art imaging tools to study how crops adapt to environmental changes |
Courses list
October 2022
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Compulsory | ||||
| How to Write a Molecular and Cellular Paper | 4 | 20 | English | |
January 2023
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Biostatistics for Molecular and Cellular Biology | 5 | 27 | English | |
February 2023
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Compulsory | ||||
| Molecular and Cellular Biology. Methods and Communication of Results | 4 | 24 | English | |
June 2023
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Host- Pathogen Interaction | 3 | 18 | English | |
| Non-Coding Rna | 2 | 12 | English | |
Following the programme of study
Contacts
Office and services for PhD students and companies